Researchers at US "Northwestern Medicine" have found that the virus of human immune deficiency (HIV-1) interacts with protein fragments related to Alzheimer's disease in the brain. This can explain why some HIV patients develop cognitive disorders. The results were published in the magazine of Proceedings of the National Academy of Sciences (PNAs).
Scientists have explained that HIV usually multiplies, "collecting" new viral particles on the surface of the cells. But in the brain it uses another path. It is formed inside the "bubbles" of a cell's special "small containers, through which the cells sort and send proteins."
Researchers have found that this process is hampered by a protein behind a protein named C99. It is formed during the destruction of the prior to the prior to the prior to the prior to the prior to the protein (AP), which plays an important role in the development of Alzheimer's disease. When C99 closes the path of the virus, HIV is trying to destroy it. However, this "protection" turns itself against the body. As a result, the formation of poisonous amyloids damaging brain cells increases.
In other words, the virus and neurodegenerative processes compete for the same mobile mechanisms. To multiply the virus needs cell resources, but the use of these resources accelerates harmful proteins related to Alzheimer's disease.
"Our study shows that the ways of multiplication of HIV and the mechanisms of amyloids are closely linked. This competition decides how active the virus can spread and how quickly the brain cells are damaged, "said one of the authors of the study, Professor Mojga Laghavi.
Translation of: Euromedia24.com
