Scientists at the Northwestern University (USA) have discovered a group of 16 protein, which affect the development of Parkinson's disease in the case of cell waste processing and "bad" genetics. The results of the research were published in Science.
Scientists were trying to understand why some people were in genetic mutations to Parkinson's illness, while others did not. During the new study, they used modern CRISPR intervention technology to analyze all genes of human genome.
Scientists have discovered a group of 16 proteins called Commander. This group plays a key role in delivering proteins in the "Waste Processing Stations". Violations of this system have long been related to neurodegenerative diseases, including the development of Parkinson's disease.
A special attention was paid to GBA1 in the work. Its undesirable options are already known as one of the main risk factors in Parkinson's disease and Liy bodies. However, so far it has been unclear why GBA1 mutations do not always lead to illness. The new study shows that the additional mutations of the genes of Commander Complex reduce the activity of an important enzyme called GCASE in lisosomes, thus increasing the danger of disease.
The data analysis of the data of the two independent groups, the UK Biobank and the AMP-PD project confirmed that the options loss of Commander gene functions are more common to patients with Parkinson's disease.
"This suggests that additional genetic changes can indeed increase the risk of Parkinson's disease," said Dr. Dimitri Creents, who led the study and headed the Finaberg Institute.
The resulting data opens new opportunities for the development of new methods of treatment. Scientists say the drugs, which are aimed at the proteins of the Commander Complex, can strengthen the lisosome function and slow down the disease.
Now the researchers plan to find out if the Commander complex can play a similar role in other neurodegenerative diseases that include lysosomal dysfunction.
Translation of: Euromedia24.com
