Scientists from Nankin's Chinese Medicine University have found that a repertal injury, which is sometimes a complexity occurring after heart surgery, arises from special proteins that cause an aggressive reaction of immune cells. The results of the study were published in Research.
Rapefree injury occurs when the blood flow of a heart or other organ is temporarily terminated, for example, due to a vascular flap or surgery, suddenly recovers. This sudden blood flow causes oxygen and nutrients to organ, but also generates excess of jet molecules that damage cells.
In addition, after the restoration of blood flow, the cells of the immune system, which are called neutrophiles, begin to secure their DNA chains, forming the so-called DNA networks. According to scientists, these networks "stick" to the walls of blood vessels and hurt them.
As experts have shown, the process is activated with a protein called MICU3. It makes Mitrokondries, the cell "power plants", absorb very much calcium. This leads to the destruction of mitochondries, and the cell starts to actively destroy them. This "demolition" is extremely intense and motivates immune cells to secrete DNA networks.
In addition, MICU3 is connected to another protein, VDAC1, which increases the flow of calcium even more MitroDryrias. For the chain of these events, additional "fuel" is lactate, a substance that is formed during glucose processing. At the same time, it connects Micu3 gene and helps protein longer.
According to the authors, if we learn to block MICU3 or break its contact with VDAC1, we can reduce heart damage after heart attacks and reduce the side effects of stence. This is especially important for diabetes and is a high-risk patients with ischemic heart disease.
Translation of: Euromedia24.com
