Scientists from the University of John Hopkins, the University of John Hopkins, have discovered a small gene, S10s, which can be penetrated in the heart to prevent arrhythmias. The results of the study were published in the EUROPEAN HEART JOURNAL (EHJ) magazine.
According to Cardiologist and the authors of the research, Gerard Boych, the fast transfer of pulses is necessary to maintain a stable heart rhythm. The violation of this conduct can lead to life-threatening arrival, especially in patients with heart failure, or genetic disorders.
Within the framework of the study, a group of scientists first solved the problem of slowdowning the conductivity, introducing a new gene in the muscle cells of the heart. Until now, effective genes were too large to transmit cells through a viral vector. However, the team has discovered a S110A-short (S10s) gene, which is small enough to transport cells using AAV one of the most effective platforms to deliver genes.
The results of the experiment showed that the introduction of this gene improves the communication of pulses in the heart, which can be a basis for the new method of treatment of arrhythmia. The research team has successfully demonstrated the results of different animal models, human heart muscle cells and human heart computing model.
"Additional studies are needed to assess whether this approach can be applied in clinical practice. If so, its use can significantly reduce the occasion of arrhythmia and improve the survival of patients, "said the boynel.
Translation of: Euromedia24.com
